Clinical Development Evidence For Clinical Effectiveness

Clinical Development Evidence for Clinical Effectiveness There were various clinical trials completed and revived, only made possible by the preclinical work. These were done under various conditions at differing dosages and times of infusion and under different conditions. The ECLIPSE trials were made up of 3 studies to test clevidipine against 3 common perioperative antihypertensives which were nitro-glycerine, sodium nitroprusside, and nicardipine (which is usually a postoperative drug due to long half-life) in 1:1 ratio of clevidipine patients to other drug patients. Necessary ethics and control methods were implemented among the patients, 579 patients who were in the sodium nitroprusside vs. clevidipine study; 546 in the nitro-glycerine study and 381 in the nicardipine study (total 1506 patients only 1410 were eligible for analysis). [1] [2] The studies found that less clevidipine was needed to achieve the same effects as nitro-glycerine and nicardipine. Similar amounts were used to achieve similar effects verses sodium nitroprusside, but a secondary hypertensive tended to be need more often in the sodium nitroprusside-traded group versus the clevidipine group. The studies also found little differences in the mortality or adverse out comes with-in 30 days. The trials reported that clevidipine was significantly more effective at maintaining BP within a healthy range. The end conclusion drawn was that clevidipine was a safe and effective means of treating acuteShow MoreRelatedAnalysis And Application Of Clinical Practice Guidelines Essay1337 Words   |  6 PagesAnalysis and Application of Clinical Practice Guidelines: Prevention of Pressure Ulcers Pressure Ulcers are a common issue for hospitals and long-term nursing facilities nationwide. Annually an estimated cost of $143 million is spent on hospital acquired conditions which include pressure ulcers (Kandilov, Coomer, Dalton, 2014). 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